Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Applies only to oral form of both agents. commonly, these are "preferred" (on formulary) brand drugs. Modify Therapy/Monitor Closely. Potential for additive CNS stimulation. Comment: Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Use Caution/Monitor. Additive pressor effect. Use Caution/Monitor. Contact the applicable plan Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. nortriptyline, methylphenidate. This drug is available at a higher level co-pay. Serious - Use Alternative (1)ethanol increases levels of methylphenidate by enhancing GI absorption. ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (2)famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Interaction more likely in certain predisposed pts. Concerta is a long-acting drug: It increases dopamine steadily. Monitor Closely (1)asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Risk of acute hypertensive episode. Volume III, Number 5 | November/December 2000 . Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)lansoprazole decreases effects of methylphenidate by enhancing GI absorption. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (1)methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Monitor Closely (3)serdexmethylphenidate/dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. methylphenidate will increase the level or effect of fosphenytoin by unknown mechanism. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Monitor BP. Contraindicated. Drug . Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Monitor BP. Either increases effects of the other by serotonin levels. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. only. Monitor Closely (1)methylphenidate will decrease the level or effect of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Either increases effects of the other by pharmacodynamic synergism. Interaction more likely in certain predisposed pts. Monitor BP. green tea, methylphenidate. Selegiline. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor BP. Risk of acute hypertensive episode. The difference between Concerta and Ritalin is how long the. Modify Therapy/Monitor Closely. Methylphenidate may diminish antihypertensive effects. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP. Applies only to oral form of both agents. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. Monitor BP. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. Interaction more likely in certain predisposed pts. Other (see comment). Interaction more likely in certain predisposed pts. Modify Therapy/Monitor Closely. Use Caution/Monitor. Other (see comment). Sympathomimetics can antagonize the activity of some antihypertensive agents. only.fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Concerta is long-acting Ritalin (methylphenidate). Monitor Closely (1)prochlorperazine, methylphenidate. Contraindicated. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Interaction more likely in certain predisposed pts. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Modify Therapy/Monitor Closely. isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. The recipient will receive more details and instructions to access this offer. Monitor BP. provider for the most current information. Minor/Significance Unknown. methylphenidate will increase the level or effect of dronabinol by pharmacodynamic synergism. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)bromocriptine, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Risk of acute hypertensive episode. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. These cannot be substituted on a milligram-per-milligram basis. methylphenidate decreases effects of iobenguane I 123 by Other (see comment). only. Use Caution/Monitor. Risk of acute hypertensive episode. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Other (see comment). Monitor BP. Use Caution/Monitor. ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Use Caution/Monitor. Monitor BP. Contraindicated. Use Caution/Monitor. methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Use Caution/Monitor. Contraindicated. Other (see comment). Minor/Significance Unknown. Use Caution/Monitor. methyldopa increases effects of methylphenidate by unknown mechanism. Use Caution/Monitor. Monitor BP. Monitor Closely (1)metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Modify Therapy/Monitor Closely. A Patient Handout is not currently available for this monograph. Manage and view all your plans together even plans in different states. Serious - Use Alternative (1)ergoloid mesylates, methylphenidate. Use Caution/Monitor. Table 3: Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Conclusion Tranylcypromine. Contraindicated. Monitor Closely (1)dopamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Use Caution/Monitor. 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. norepinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Risk of acute hypertensive episode. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Modify Therapy/Monitor Closely. Other (see comment). Contraindicated (1)safinamide increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. ethanol increases levels of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Monitor Closely (1)loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor BP. Mechanism: pharmacodynamic synergism. Monitor Closely (1)dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Monitor Closely (1)armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode. calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Risk of acute hypertensive episode. Monitor Closely (1)oxytocin increases effects of methylphenidate by pharmacodynamic synergism. Serious - Use Alternative (1)doxapram increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Use Caution/Monitor. Avoid or Use Alternate Drug. Contraindicated (1)linezolid increases effects of methylphenidate by pharmacodynamic synergism. aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Monitor Closely (1)sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Most Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. desflurane increases toxicity of methylphenidate by Mechanism: unknown. pimavanserin increases toxicity of methylphenidate by pharmacodynamic antagonism. 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