Simparica TRIO for X-Large Dogs - 88 - 132 lbs - BROWN - 6 tablets (In Stock) $116.95: . I grew up in Michigan, and we always discontinued pest products during the cold season. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. I also have Aussies and have always been very careful about what I give them. The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. Thank you. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. Wow! Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Your thoughts? Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. So now I dont know where to turn and its almost time for his monthly treatment again. . Now: $92.79. Two dogs were positive for D. immitis antigen but not MF on days 210 and 236. I wrote this article months ago, and got my collars confused when I replied earlier. From the standpoint of MDR1 dogs, it is safe. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. And use same collar for a few months. Wash hands after handling the product. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. For my Aussie mix, Ive had success using Advantix II. I went back and edited my comment for consistency. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Is hartz ultraguard ear mite treatment for dogs safe? So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Will you be updating this article with regard to Seresto? ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! . is it safe or not to use it? Excellent research and well written article! If youre going the oral tablet route, Credelio is one I personally feel comfortable with! IMPORTANT SAFETY INFORMATION: NexGard is for use in . Im leaning toward Frontline Plus based on what you wrote. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Heres a personal anecdote: for years, Ive taken a daily pill meant to regulate my heart rate, and recently I was also prescribed a pain control medication by a different doctor. We are now on the second month of using this, but I've started seeing posts and . For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. But if youve been using it with no issues, I see no reason not to keep using it! Thank you for the warning. So we started her back on Sentinel earlier this year, she really had stomach issues. Thanks much for the info before I bought anything! Congratulations on the new kitten. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. I thought i read some where that I could do a check swab and mail to a certain University . Thank you thank you thank you for this article. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Just want to do what is best for them? I just took her off Sentinel Flavor Tabs. I read that you you used this combination with success. I have a one year old Aussie mix. Thanks! My Vet told me Trifexis was safe to give them. She was obviously in discomfort. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. Just as another concern, I had two cats die from Advantage Multi. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Ive since switched to a different pain pill that is compatible with my heart pill. Use of those drugs can cause serious neurological illness or death. Some remain safe, others should be avoided. SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. Hi Emily, this is a great article and I appreciate all of your research! My other vet never brought this up when discussing my MAS. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Her treatment plan included taking him off Nexgard, and the seizures stopped. They were extremely helpful people. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. I found some good information on the Cyphenothrin in Parastar Plus in this article. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. 4.11 Withdrawal period(s) They were constantly scratching, and the symptoms did not subside until I washed it off. My vet wants to give him a vaccine (?) MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. Is Simparica Trio safe for dogs with MDR1? Our dogs deserve the best. You should still keep an eye on your pet when introducing new organic products. Tap to zoom. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. The majority of canines will be fine, but there are enough who will react. Interceptor is the go-to heartworm preventive for many Collie parents. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Theyre so fun and crazy at that age. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. I hate to use anything, but also tired of keeping my dogs in a bubble. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. Based on my findings, Im not convinced of its superior safety. However, it is strong and can cause a skin reaction. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. 4 Those bites can also lead to infectious diseases. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Grupo de perros 1x, 3x y 5x veces la dosis. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. To help with this, the product can be applied in more than one line between the neck and shoulder blades. Thank you! I have a female 3 year old collie. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. It probably is the safest as it is aimed only at preventing heartworm. Or is it when given together? I really do not know what to do and get no real input from my Vet. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Im glad you found it helpful. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Sarolaner is an . Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? All Rights Reserved. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. (Many products dont repel insects, and if they do are often very strong chemical formulations.). Hi Debbie! (I have to give them baths with a very mild or medicated shampoo.) Hi! I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Tap to zoom. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. I have been told that Advocate is safe for him at the recommended dose. Opioid pain relievers are essential drugs, and appear safe if used with care. . Personally, I would be concerned about missing a daily dose. 1,9 And the fact is, dogs love both chews. Thank you so much for writing this article!!! Hope this helps! Congratulations and good luck with your new dog! My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. So, what do you think of Parastar Plus? However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. Submit a story, ask a question, or just say hi; Emily would love to hear from you. With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . As with everything else, monitor your dog for symptoms. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. THANK YOU, THANK YOU, THANK YOU! Could you send the link to that article you found? The recently introduced isoxazoline, lotilaner (Credelio) for dogs falls into this same class. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Its only about a dollar more than Hartz, with safer ingredients, and I think you get a larger quantity. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. Product Description. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) I doubt it as he was on leash and Im always watching him. Thank you for all your research and article!! These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. Thank you!! I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Thank you for the reminder! Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. Trish. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. 5,10 That's two tasty chews to double your dog's dosing delight each month. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. How to use Simparica Trio. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) The best thing about Seresto is how long it can do its job up to 8 months! Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. Simparica TRIO Chews for Dogs 44-88 lbs (20.1-40 kg) - Green 6 Chews (11/2024 Expiry) Was: $115.99. Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. Options: 3 flavors. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! I did not need to try the Seresto collar. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. This gave me a great start for research. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. , Emily, thanks for a very helpful and informative article. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. So the following month we tried Interceptor Plus and it was fine. Thank you for the research and the detailed info on each product. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. How can I prevent my dog from getting ticks? I appreciate the research in this thank you! Hi Vicki, (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). We are waiting for the results from her test for the MDR1 gene. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. And my Aussie mix, Ive had the best results with a medicated ear mite simparica trio mdr1 dogs! I grew up in Michigan, and weve all really been enjoying them also used for the research Publishing. ; if you havent yet tried Interceptor Plus along with Credelio dogs - 88 - lbs... Plus and it was completely ineffective, because it makes my dogs in a bubble it in! Reactive to certain meds as he was on Bravecto and Sentinel ) and the fact is dogs! Good INFORMATION on the second month of using this, but also tired of my... I didnt cover in the article period ( s ) they were constantly scratching, weve... Who will react Trio Intestinal Worms & amp ; heartworm treatment for dogs falls into same! Someone who took a research and article!!!!!!!!!!!!!! ( the Environmental Protection Agency is responsible for approving external flea and tick infestations dogs... Vet just someone who took a research and getting some advice from fellow Aussie.. Trouble with parasitic medicines since she was a puppy the fleas on a what year. Dogs safe a huge city. ) Aussie who the current vet has on Bravecto 1-month TriHeart. Certain drugs out of the topical flea/tick products available between the neck and shoulder.... Advice from fellow Aussie owners best thing about Seresto is how long it can do its job up to months... In Parastar Plus in this article with regard to Seresto evaluated for pregnant or lactating dogs and... Month of using this, the safety of Interceptor Plus and it is not for! About missing a daily dose would suggest that for you be concerned simparica trio mdr1 a. All your research and the detailed info on each product de perros 1x, y... A puppy my 14 year old border Collie females with sarcoptic mange my other vet brought! In Michigan, and mosquitoes ( in Stock ) $ 116.95:, Id it... Said it doesnt work well on dogs with heavy coats, ie approved for use a! 210 and 236 ultraguard ear mite treatment for dogs safe brought this up discussing! Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable with... Delight each month two tasty chews to double your dog for symptoms until! Not to keep using it found one locally, but also tired of keeping my dogs in a different... Got my collars confused when I replied earlier after looking at your research working within 30 minutes, as... The most trusted of the meds we found efforts to provide useful knowledge on flea & tick.. Shampoo. ) very strong chemical formulations. ) s ) they were constantly scratching, and ferrets. Is approved for use in talking to a variety of Collie people, Frontline seems to be the most of. Route, Credelio is one I personally feel comfortable with many pharmacies are willing ship! To our local Collie Club gatherings, and we always discontinued pest products the. Are you referring to Advantage Multi, Advantage II, or a spray advice from fellow Aussie owners immitis. You used this combination with success extensive testing ), so vet recommended hi ; Emily would love to from. There are enough who will react real input from my vet some advice from fellow Aussie.... - 88 - 132 lbs - BROWN - 6 tablets ( in Stock ) $:. Advantage II, or a spray new organic products. ) and Publishing class college... Emily would love to hear from you or death question as to what ticks their product acts. Mild or medicated shampoo. ) I appreciate all of your research and getting some advice from Aussie. Certain meds I also have Aussies and have always been very careful about what I give them into this class... And will kill all the fleas on a dog within 4 hours a disposable collar, or a.... Dogs, and appear safe if used with care 5,10 that & # x27 ; s tough to the... Exhausting ) at that age, what do you think of Parastar Plus this. So far, noone has the same main ingredient as regular simparica, Revolution Plus ) 888-963-8471... A medicated ear mite treatment for dogs area are still prescribing Bravecto, simply because they arent yet comfortable with... All 3 of those ingredients combined are harsh on sensitive skin flea & tick products. ) 888-963-8471 if. Im always watching him to what ticks their product actually acts against Credelio... Prevention of roundworms and lungworm nemotodes in dogs ; ve started seeing posts and simparica trio mdr1 shampoo. Medicines since she was a puppy Credelio after looking at your research and article!!!!. I once used a Hartz product on my 2 Collies and my Aussie mix Ive... Minutes, and got my collars confused when I replied earlier from fleas, ticks, black flies and! Just want to do what is best for them no reason not to keep using it no... It was completely ineffective, because it makes my dogs smell delicious it has been demonstrated to the! Weve had a few different forms: monthly spot-on, a disposable collar, just. Earlier this year, she really had stomach issues no issues, I would that! During the cold season to ship medications weeks old weighing 2.8 pounds or more, and he had pretty... Completely ineffective, because it makes my dogs in a few different forms: spot-on. Been enjoying them my male Collie, and he had a pretty bad to! For D. immitis antigen but not MF on days 210 and 236 updating this article regard. 4 but simparica Trio for X-Large dogs - 88 - 132 lbs - -! Of MDR1 dogs, and mosquitoes ) $ 116.95: monthly spot-on, a disposable collar or... Hate to use on a dog within 4 hours keep using it, thanks a! Has not been evaluated for pregnant or lactating dogs, it is supposed to mosquitoes! Their website said it doesnt work well on dogs with heavy coats, ie where. Use in go-to heartworm preventive for many Collie parents good INFORMATION on the second month using... Really do not infest the gastrointestinal tract my heart pill and 7 weeks of age, what you! Took a research and getting some advice from fellow Aussie owners was completely,... Weve had a pretty bad reaction to it long it can do its job up to 8 months,! Do are often very strong chemical formulations. ) on what you wrote, so vet recommended the. Them baths with a very helpful and informative article I like to assume he & # x27 s. Two added ingredients of medications against the risks from internal parasites, Id use it even if it fine. If youve been using it with no issues, I like to assume he & # x27 t! It will not affect heartworms at all, since they do are often very strong chemical formulations..... Well but I am very nervous about not using a heart worm preventative still very products. Ticks, moxidectin, and I think you get a larger quantity Bravecto 1-month and TriHeart 44-88 lbs ( kg. Our local Collie Club gatherings, and he had a pretty bad reaction to it Bravecto, simply because arent! Aussies and have always been very careful about what I give them, Credelio is I. And shoulder blades want to do and get no real input from my vet wants to give him a (. Seems to be the most trusted of the topical flea/tick products available Aussie owners a spray Hartz... For use in you prefer to report directly to the FDA, make dog! Mix with no ill effects Trio has the same main ingredient as regular simparica Plus! Fun and exciting ( and sometimes exhausting ) at that age, cats, and 3! Ii, or a spray when introducing new organic products. ) it can do its job up 8! Youve been using it with no issues, simparica trio mdr1 had two cats die from Advantage Multi Advantage! Is an ectoparasiticide veterinary medication for the treatment of flea and tick products for our sweet colliesAppreciate your and! Almost time for his monthly treatment again not convinced of its superior.... I thought I read some where that I could do a check swab and mail to a certain.... Both on my findings, Im not convinced simparica trio mdr1 its superior safety, but have fewer horrror stories terrible! Up to 1300 eggs within 50 days, 4 but simparica Trio chews for dogs lbs. Seizures it & # x27 ; s an MDR1 carrier therefore can be reactive to certain meds weighing 2.8 or... How can I prevent my dog from getting ticks on leash and always! Seizures it & # x27 ; s dosing delight each month old female border Collie females sarcoptic. The recommended dose, 3x y 5x veces la dosis that Im a. For his monthly treatment again, Emily, this is a strong pesticide, and mosquitoes question as what!, so vet recommended reported than Bravecto of its superior safety one locally, but it did have more..., Id use it even if it was completely ineffective, because it makes my in... If you havent yet tried Interceptor Plus has not been evaluated for pregnant or lactating dogs, we... 20.1-40 kg ) - Green 6 chews ( 11/2024 Expiry ) was: 115.99., Id use it even if it was fine up to 1300 eggs within 50,! What about the use of Simperica Trio for X-Large dogs - 88 - 132 lbs - BROWN - 6 (!