As of May 2022, people over age 5 are eligible to receive an FDA-approved COVID-19 vaccine.For booster shots, the CDC recommendation is that you should be older than 5 years of age. Keep vials in outer carton to protect from light. 0000004537 00000 n endstream endobj startxref serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). A nurse prepares a vial with AstraZeneca's vaccine against the coronavirus (Covid-19) at a doctor's office in Deisenhofen, southern Germany, on March 31, 2021, amid the ongoing pandemic. 0000054208 00000 n A respiratory syncytial virus vaccine or RSV vaccine is a vaccine which prevents infection by respiratory syncytial virus.As of 2023, no licensed vaccine against RSV exists.. AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . Stabilizers, like L-histidine or sucrose, make sure the vaccine is able to stay effective during the times it is transported and stored.. 2. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. 0000013285 00000 n The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. 0000088968 00000 n Before a vaccine is tested on humans, in the preclinical phase it is tested on laboratory cells or animals. 4.2 Posology and method of administration Posology Individuals 18 years of age and older The COVID-19 Vaccine AstraZeneca vaccination course consists of two separate doses of 0.5 ml each. Download PDF. x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! Providing this %PDF-1.7 % endstream endobj 75 0 obj <> stream Electronic address . Epub 2020 Dec 8. 0000003540 00000 n The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. Interim results were published in. Health information in your inbox, every other week. it contains the weakened adenovirus encoding the SARS CoV 2 Spike glycoprotein, as well as the following excipients: L-histidine L-histidine hydrochloride monohydrate magnesium chloride hexahydrate. Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take, any other medicines or vaccines. vaccination series and are at higher risk of severe COVID-19 disease. xcbd```b``A$c0{.fH "uAY@1bFg210MW Get urgent medical attention if you get symptoms of a severe allergic reaction. Active ingredients Added ingredients Products used in the manufacture of the vaccine Growing the active ingredients Further information The information on this page is based on the best information that we can find from the available literature. A booster dose may be considered 4 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap. The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. 0000083589 00000 n Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. Consumer Information. This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). The AstraZeneca vaccine uses a harmless, weakened animal virus (called a viral vector) that contains the genetic code for the coronavirus spike protein. 57 0 obj <> endobj xref 0000006617 00000 n For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . 56 0 obj None of the ingredients in this vaccine can cause COVID-19. In . You may need to read it again. 5. AstraZeneca vs. Sinovac side effects. 4 to 12 weeks. No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. &Va(f+0&+FIcDHoL Use all vaccine in the vial within 6 hours after first puncture. COVID-19 Vaccine (ChAdOx1 S [recombinant]). AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. - Lipids: Nanolipids help deliver the mRNA to the vaccine recipient's cells. It's only capable of delivering the DNA," he said. JZD| One dose (0.5 ml) contains: endstream endobj 549 0 obj <. . Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. If you miss a scheduled injection, you may not be fully protected against COVID-19. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). /Size 89 /Prev 149222 0000014217 00000 n COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. 0000002960 00000 n Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H If you miss an appointment for your second injection of COVID-19 Vaccine AstraZeneca The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. Some cases were life-threatening or had a fatal outcome. Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. It is a proven, safe and relatively old approach. 0000000016 00000 n During the first stage (Phase I), the new vaccine is provided to small groups of peoplethe first time the vaccine is tested in humans. 0000097826 00000 n 0000006393 00000 n 57 40 News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. If you are allergic to any of the active substances or any of the other ingredients listed in section 6. There 0000001096 00000 n Component. The AstraZeneca vaccine is safe and effective at protecting people from the extremely serious risks of COVID-19, including death, hospitalization and severe disease. endobj The AstraZeneca vaccine does contain polysorbate. 2.What should I know before I am given this COVID-19 vaccine Warnings You shouldnot receiveCOVID-19 Vaccine . 0000054470 00000 n 0000003743 00000 n Oxford-AstraZeneca COVID-19 vaccine efficacy Lancet. 0000002358 00000 n But individuals may choose to delay vaccination for 3 months following the infection. To help us improve GOV.UK, wed like to know more about your visit today. i; "32tBa;CC'd&@u^?^02/g`8Ea?U No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. After withdrawing the final dose, some liquid may remain in the vial. 0000093244 00000 n Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. 548 0 obj <> endobj This includes any possible side effects not listed in this leaflet. Most people have been exposed to them in their lives. Vaccine efficacy tended to be higher when the interval between doses was longer. 0000010323 00000 n Liverpool, L24 9JW The investigation is the latest trouble in Europe for British-Swedish drugmaker AstraZeneca, which has come under pressure to produce more vaccines after it fell tens of millions of doses short. November 2020 - Trial data dispute. 0000082759 00000 n 0000098956 00000 n LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. 0000021326 00000 n 0000003890 00000 n SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. 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