No worries, though! Lions mane mushrooms, also known as hou tou gu or yamabushitake, have both culinary and medicinal uses in Asian countries like China, India, Japan, and Korea (1). 7 min read, November 29, 2022 One study showed that rats with nerve damage receiving a daily extract of lions mane mushrooms had quicker nerve regeneration than control animals. The brains ability to grow and form new connections typically declines with age, which may explain why mental functioning worsens in many older adults (2). By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. : Fr.) 2012;2012:464238. Sheng, X., Yan, J., Meng, Y., Kang, Y., Han, Z., Tai, G., Cheng, H. (2017, March 22). Research has found that lions mane may protect against dementia, reduce mild symptoms of anxiety and depression, and help repair nerve damage. Xu CP, Liu WW, Liu FX, et al. In addition, research has also shown(6) this traditional Chinese medicine initiates the death of cancer cells (apoptosis). Here's what the research says. This article lists 13 foods that have powerful anti-inflammatory effects to help lower chronic inflammation. Protective effect of ethanol extracts of, Zhang, J., An, S., Hu, W., Teng, M., Wang, X., Qu, Y., Wang, D. (2016, November 1). It also seems to help protect the lining in the Theres no standard dosage for lions mane mushrooms. Monitor your blood sugar closely. Products should be free of contaminants like mold, pesticides, and other potentially harmful chemicals used during manufacturing. Press question mark to learn the rest of the keyboard shortcuts. Reduction of depression and anxiety by 4 weeks. Most studies on lions mane mushrooms have used animals, but it appears to be safe to eat the mushrooms in moderate quantities, as people do in many countries in Asia. class="article__title title lions-mane-dosage-guide-how-much-should-you-take-daily"> There have been documented cases of people experiencing difficulty breathing or skin rashes after exposure to lions mane mushrooms, likely related to allergies (63, 64). Overall, research suggests that lions mane extract may help inhibit the development of ulcers, but more research involving humans is needed. Effects of amycenone on serum levels of tumor necrosis factor-, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration [Abstract]. Damage to the nervous system can have significant effects on health. Int J Med Mushrooms. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull. View abstract. It's also important to consider any potential interactions with other medications or supplements you may be taking and any underlying medical conditions. Possible health benefits include lowering cancer risk and boosting the immune system. Chronically high blood sugar levels eventually cause complications like kidney disease, nerve damage in the hands and feet, and vision loss. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. All rights reserved. Vegetables are a very important food group on a low-carb diet. People can eat them or take them in the form of supplements. Lion's mane mushroom may possess neuroprotective effects, suggesting benefit in neurodegenerative disease as well as in the management of nerve injury. All functional mushroom supplements are different, but they may interact with medications designed to mange blood pressure, blood sugar, hormone levels, or blood clotting. Likewise, taking lion's mane along with anticoagulant/antiplatelet drugs can cause blood clotting difficulties that can result in bleeding or bruising. View abstract. 2015;9(2):483-487. Biosci Biotechnol Biochem. A: In the clinical study on lion mane mushrooms effect on anxiety and depression, there showed no risk of addiction, unlike traditional antidepressants or psychoactive drugs. 2011;59(18):9861-9. (59). (Aphyllophoromycetideae) in accelerating wound healing in rats. Lion's mane may also interact with certain medications, including blood thinners and immunosuppressants. What are chaga mushrooms? Inflammation contributes to many medical conditions, including diabetes, heart disease, and autoimmune diseases. A high-quality Lion's mane mushroom extract is highly potent. The time it takes for Lion's mane to work varies from person to person, depending on factors such as age, overall health, and the reason for taking Lion's mane. Read More: See howLion's mane promotes neurogenesis. to cook fresh Lion's mane fruiting bodies. Therapeutic Research Faculty 2020. 2018;21(2):174-180. Other researchers have concluded that the mushrooms may have the potential to treat or prevent diseases that cause a decline in cognitive health, such as Parkinsons disease and Alzheimers disease. The safety and effectiveness of lions mane supplements are less apparent because dietary supplements do not have the same regulations as food and drug products. View abstract. This article has been vetted by the Onnit Advisory Board. However, the cultivation methods may affect the mushrooms medicinal properties. A 2020 study of people with mild Alzheimers disease found that supplementation with 1 gram of lions mane mushroom daily for 49 weeks significantly improved cognitive test scores compared with a placebo (7). On the other hand, a weak immune system puts the body at a higher risk of developing infectious diseases. Abdulla, M. A., Fard, A. One 2010 study of rats fed a high fat diet and given daily doses of lions mane extract showed 27% lower triglyceride levels and 42% less weight gain after 28 days (28). Ulcers can form anywhere along the digestive tract, including the stomach, small intestine, and large intestine. In general, there are no definitive answers to whether Lion's Mane interacts with any particular medications, so you may be able to work with your doctor and pay close attention to your Lion's Mane Dosage and possible side effects while creating your dosing regimen. Our website services, content, and products are for informational purposes only. Int J Biol Macromol. In any case, you should discontinue use and talk to your doctor if you experience any adverse reactions after taking Lions Mane. Our team thoroughly researches and evaluates the recommendations we make on our site. One study involving menopausal women experiencing irritability and low concentration found that supplementing with lions mane showed improvements in feelings of depression and anxiety. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The antioxidant properties of lions mane mushrooms may play a role in cancer prevention or treatment. Lions mane extract can also reduce inflammation and prevent tissue damage in other intestinal areas. In rare cases, Lion's mane can also cause allergic reactions, including itching, skin rashes, and difficulty breathing. Medical News Today only shows you brands and products that we stand behind. Hericium erinaceus extract reduces anxiety and depressive behaviors by promoting hippocampal neurogenesis in the adult mouse brain. This dosage can also increase insulin levels and reduce the risk of pain associated with diabetes complications like neuropathy. This dosage is enough to stimulate the Nerve Growth Factor (NGF) production and fight brain health issues like Alzheimer's and dementia. Therefore, you must use a high dosage of fresh mushrooms to get the same benefits as supplements. 2009;23(3):367-72. If you experience discomfort or side effects, reduce your dosage. Since lion's mane is an anti-inflammatory on top of everything else, it might be able to alleviate any inflammation associated with mental health. Lai PL, Naidu M, Sabaratnam V, et al. Tsai-Teng T, Chin-Chu C, Li-Ya L, et al. 2015;78(1):146-54. Iron is an essential nutrient that plays an important role in many bodily functions. Active compounds in the edible Lion's Mane mushroom can help promote neurogenesis and enhance memory, a new study reports. Lion's Mane Dosage Guide: How Much Should You Take Daily? There were also no withdrawal symptoms, other than mild symptoms of depression returning when taken off lions mane supplement. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. For example,pure Lion's mane extract is so potent that a dosage of 250 mg to 750 mg will be enough to produce the desired health benefits. Mushrooms are hearty and versatile, making them an excellent substitute when a recipe calls for meat. Brain or spinal cord injuries can cause various adverse medical outcomes. View abstract. The reishi mushroom is popular in Eastern medicine and claimed to have various health benefits. I am new to longecity and the subject of nootropics. View abstract. View abstract. Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. View abstract. Lions mane is a very safe supplement, hiding no Medications that are designed to thin the blood or slow blood clotting may also be unsafe to pair with Lions Mane. Rossi P, Cesaroni V, Brandalise F, et al. 2003;67(6):1292-8. These statements have not been evaluated by the Food and Drug Administration. Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull. When this enzyme is blocked, the body is unable to digest and absorb carbs as effectively, which results in lower blood sugar levels. Reishi mushrooms have many purported benefits, including boosting the immune system and shrinking tumors. Medicinal mushrooms are making their namesake for carrying a heavy dose of healing compounds. Evid Based Complement Alternat Med. Heart health. I an bipolar and recently diagnosed with Lupus. The effects of lions mane on brain function may also prove to be beneficial in supporting those who suffer from depression and anxiety. For example, if each capsule contains 500 mg of Lion's mane powder, you can start with two daily tablets, giving you 1,000 mg. After that, you can increase your intake to 4 tablets, giving you 2,000 mg daily. However, when using fresh fruiting bodies, you may want to increase the dosage to 5,000 mg daily as fruiting bodies are much less potent. These two conditions are characterized by memory loss. 2011;2(6):348-56. Chaga mushrooms may have a range of health benefits, from lowering blood pressure to preventing cancer. However, when the same study was repeated in patients with Crohns disease, the benefits were roughly the same as with placebo (26). Be patient and consistent with taking Lion's mane supplement, as its effects accumulate over time. View abstract. Evid Based Complement Alternat Med. Lions mane mushrooms contain compounds that stimulate brain cell growth and protect them from damage caused by Alzheimers disease. Lee JS, Hong EK. Zhang CC, Yin X, Cao CY, et al. J Biomed Sci. A double-blind study of effectiveness of hericium erinaceus pers therapy on chronic atrophic gastritis. Use of this site constitutes acceptance of our, Press J to jump to the feed. Therefore, you must use a high dosage of fresh mushrooms to get the same benefits as supplements. However, anyone who is allergic or sensitive to mushrooms should avoid lions mane since its a mushroom species. View abstract. People who experience adverse reactions to lions mane mushrooms should stop using them and seek immediate medical attention. However, most people with diabetes use other pharmaceutical drugs to maintain healthy blood sugar levels. Biosci Biotechnol Biochem. Choline vs Alpha-GPC: Which is the Superior Cholinergic? You may want to talk with a doctor about the right dosage for you. Lions mane mushroom and its extract have been shown to have various health benefits. J Agric Food Chem. Extracts from lions mane mushrooms may be beneficial in the treatment of anxiety and depression. 2018;20(5):485-494. Health food stores sell lions mane extract in supplement form, and both the fungus and its extracts appear to be beneficial to health. Research conducted in 2020(1) verified Lion's mane medicinal mushrooms' effectiveness as a therapy for depressive disorder. The results suggested that when mice are stressed, they have decreased levels of dopamine. Lion's Mane mushroom is considered safe when taken in recommended doses, but consuming it in excessive amounts can cause adverse reactions. Taking lion's mane mushroom along with medications that also slow blood clotting might increase the risk of bruising and bleeding. OTHER NAME(S): Bearded Tooth, Crinire de Lion, Hedgehog Fungus. Bioorg Med Chem Lett. 8 min read. Lion's mane dosages of 1-2 gm/day (1000 mg to 2000 mg per day) may have anticancer properties as suggested by in vitro and animal studies. In fact, the mushroom was not found to produce any adverse effects in rodents, even when used in high doses. Chin J Integr Med. Don't forget to spice it up with your favorite aromatics! For improving cognition, some researchers recommend 3 to 5 grams per day. Lions mane may help digestive health by fighting inflammation, which could be beneficial for people with inflammatory bowel disease (IBD). Erinacine A-enriched, Choi, W.-S., Kim, Y.-S., Park, B.-S., Kim, J.-E., & Lee, S.-E. (2013, June 30). J Ethnopharmacol. Mol Med Rep. 2015;11(5):3794-9. Some of the most common ways that these reactions present include: Read Lions Mane Side Effects to learn more. 2016;111:58-65. Taking lion's mane mushroom along with diabetes medications might cause blood sugar to drop too low. 2014;15(9):15073-89. View abstract. Consult your health care provider before taking if you are pregnant or nursing, or have any other medical conditions. Animal studies suggest that lions mane mushroom and its extracts are very safe, even at high doses. Therefore, you may want to talk to a healthcare professional to help fine-tune the dosage to fit your needs. Lion's mane, Hericium erinaceus and tiger milk, Lignosus rhinocerotis (higher basidiomycetes) medicinal mushrooms stimulate neurite outgrowth in dissociated cells of brain, spinal cord, and retina: An in vitro study [Abstract]. In addition, the best dosage of Lion's mane varies from one person to the other as different people react differently to this functional fungus. In mice with diabetic nerve damage, 6 weeks of daily lions mushroom extract significantly reduced pain, lowered blood sugar levels, and even increased antioxidant levels (34). Phan CW, Lee GS, Hong SL, et al. Read More: See our guide on thebest time to take Lion's mane. It should not be used with psychiatric drugs, antidepressants, Alzheimers and Parkinsons Pers. enjoy this read? Board Certified Physician. Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. 2015;25(22):5078-82. Lions mane mushroom may be beneficial for diabetes management by improving blood sugar management and reducing some of these side effects. I have been taking antidepressants for the last seven years. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers. 2010;74(7):1447-51. View abstract. Lion's Mane mushroom is considered safe when taken in recommended doses, but consuming it in excessive amounts can cause adverse reactions. : Fr) Pers. View abstract. Samberkar S, Gandhi S, Naidu M, et al. Have you used Lion's mane before? Lions mane mushrooms can be enjoyed raw, cooked, dried, or steeped as tea. 2013;13:253. Create an account to follow your favorite communities and start taking part in conversations. 2023 Vida Optima. In addition, the fruiting body can be consumed with soup at 5g/day. Animal and test-tube studies show that lions mane extract can kill cancer cells and slow the spread of tumors, but studies involving humans are still needed. Thank you very much for reading. Li G, Yu K, Li F, et al. Read More: Learn about Lion's mane drug interactions. It is possible that lions mane mushrooms might boost cognitive function, but the existing research is mainly on animals. Int J Biol Macromol. Lions mane mushrooms may help with the following: Antioxidants may fight both inflammation and oxidation in the body. Int J Med Mushrooms. Biomed Res. However, more extensive research is necessary for the medical community to recommend lions mane mushrooms for topical use on humans. Lions Mane stimulates the repair and creation of neurons in your brain. Dietary supplementation of lion's mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), and spatial memory in wild-type mice. Note: that theres an effective 500 mg dose of Lions Mane full-spectrum fruiting body in each dose of Mind Lab Pro Wong KH, Naidu M, David P, et al. An older Japanese study on adults aged between 50 and 80 years with mild cognitive impairment found that daily consumption of mushroom extract for 16 weeks led to higher scores on cognitive function scales compared with a placebo group. There are many different types of choline supplements, but Alpha-GPC may just be superior. Rodent studies have shown that lions mane extract may help reverse stress-related changes to neurotransmitters, including dopamine and serotonin. Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. The mushrooms can be cooked and served in dishes like risotto, pasta, or soup. Lakshmanan, H., Raman, J., David, P., Wong, K. H., Naidu, M., & Sabaratnam, V. (2016, December 24). In fact, when lions mane extract is mixed with human cancer cells in a test tube, they cause the cancer cells to die faster. MNT is the registered trade mark of Healthline Media. Phytomedicine. Wong JY, Abdulla MA, Raman J, et al. Since supplements are not regulated as strictly as pharmaceuticals in the U.S., youll need to look for a supplement that meets certain quality standards to ensure the safety and efficacy or your Lions Mane dose. Although evidence is limited, some sources suggest that it may help to lower blood pressure. : Fr) Pers. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of, Liu, J. H., Li, L., Shang, X. D., Zhang, J. L., & Tan, Q. Extracts from lions mane mushrooms may provide healing benefits for skin wounds. In one study, blood sugar levels in rats with diabetes were lower after they received lions mane mushroom extract for 4 weeks. Chang HC, Yang HL, Pan JH, et al. For example, those taking blood sugar-lowering medications may need to take the mushroom and their meds at different times to prevent interactions. Several older studies have found that lions mane extract can prevent the growth of H. pylori in a test tube, but no studies have tested whether the extract has the same effects inside the stomach (19, 20). Bioorg Med Chem Lett. Yi, Z., Shao-long, Y., Ai-hong, W., Zhi-chun, S., Ya-fen, Z., Ye-ting, X., & Yu-ling, H. (2015, April 16). ( I have read that Rhodiola can interact with antidepressants). Its easy to see why so many people want in on the potential benefits of Lions Mane, but its important to remember that all herbal remedies and functional mushrooms come with some level of risk. The most common cause for adverse reaction, however, is an adverse drug interaction. View abstract. Research suggests that they may offer a range of health benefits, including reduced inflammation and improved cognitive and heart health. Lions Mane DHT Effect: Does It Really Affects Testosterone Production? Maitake mushroom is thought to regulate systems of the body and is said to have offer several health benefits. Another 2013 animal study found that lions mane extract was more effective at preventing alcohol-induced stomach ulcers than traditional acid-lowering drugs and without any negative side effects (21). Let us know in the comments. Han ZH, Ye JM, Wang GF. Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation, (6)https://www.frontiersin.org/articles/10.3389/fphar.2019.01174/full.