2013 Feb 01; 12(3):381-2. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. The fecal microbiome of ALS patients. 2020 05; 158(6):1728-1744.e14. Arch Biochem Biophys. Brain Commun. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Front Mol Biosci. PLoS One. Transforming growth factor B and hepatic fibrosis: cause or effect? 2007 Aug; 22(8):1256-64. FASEB J. Hepatology. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. Sp1 binding activity increases in activated Ito cells. WebDavid Brenner. 1995 Sep; 9(9):1157-65. Hepatology. 2007 Nov; 2(4):243-4. Yale J Biol Med. Am J Physiol. J Gastroenterol Hepatol. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. 2019 10; 68(10):1884-1892. 2010 Sep; 139(3):987-98. Surgery. Signal transduction during liver regeneration. JCI Insight. 2009 Sep; 1(8-9):513-24. 2020; 144(8):400-412. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. Clin Gastroenterol Hepatol. Gastroenterology. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. 2017 10 16; 8(1):837. 1999 Apr 15; 162(8):4447-54. J Clin Invest. J Clin Invest. What goes up must come down: the emerging role of microRNA in fibrosis. Gastroenterology. 2012 Jul; 36(1):22-9. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. 2003 Nov; 112(9):1383-94. 1990 Dec; 9(10):777-81. 2005 Jan; 54(1):134-41. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER WebBrenners new job suits his eclecticism. 2000 Mar; 15 Suppl:D20-5. 2002 Dec; 36(6):1498-508. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. 1998 Nov; 18(11):6353-64. 1999 Jun; 29(6):1680-9. J Gastroenterol Hepatol. 2006 May; 130(6):1564-72. Am J Pathol. Thomas E. Starzl: Transplantation pioneer. Nuclear factor-kappaB in the liver: friend or foe? Regulation of collagen alpha1(I) expression in hepatic stellate cells. Gastroenterology. 1995; (33):212-4. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. 2014 Aug; 124(8):3566-78. Hepatology. Clin Gastroenterol Hepatol. Cancer Res. 1989 Sep; 30(9):1220-4. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Cell Mol Gastroenterol Hepatol. J Immunol. 2008 Feb; 25(2):249-58. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Gut. I. TNF-induced liver injury. 1992 Jun; 50(6):1203-10. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. 2009 Apr; 136(4):1423-34. 2014 Jun 10; 20(17):2854-72. 2003 Oct; 125(4):1009. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Mol Endocrinol. Am J Physiol Gastrointest Liver Physiol. Hepatology. 2003 Jan 01; 8:d69-77. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. 2012 May 22; 109(21):E1369-76. 1977 Dec; 60(6):1354-61. Nature. J Gastroenterol Hepatol. 1994 Oct 21; 269(42):26396-401. PLoS One. NOX in liver fibrosis. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. J Immunol. Medicina (Kaunas). 2008 Feb; 47(2):677-85. Molecular mechanisms of alcohol-induced hepatic fibrosis. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. Vuori will Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Int J Stroke. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Gastroenterology. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Dig Dis Sci. 2011 May; 53(5):1433-5. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Am J Physiol. 2021 08 01; 321(2):H435-H445. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Hepatol Res. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2009 Oct; 137(4):1467-1477.e5. Hepatology. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2007 May; 132(5):1937-46. Proud to be part of UC San Diego and UC San Diego Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Biochim Biophys Acta. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2010 Oct; 52(4):1420-30. 2021; 12(3):891-920. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. J Biol Chem. Transient induction of c-jun during hepatic regeneration. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. J Bone Miner Res. 2007 Apr-Jun; 6(2):83-8. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. 2003 Apr; 37(4):824-32. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. J Clin Invest. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Mol Cell Biol. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2006 May; 130(6):1886-900. Nephron. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Transplantation. Alteration of interferon-a/ receptors in chronic hepatitis B patients. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. 2020; 15(6):e0234038. 2000 Feb; 88(2):142-9. Am J Physiol Cell Physiol. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 1994 Dec 09; 269(49):30789-97. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. 2014 Apr 29; 63(16):1626-33. 2008 Apr 15; 5(3):338-42. 2016; 7:47. Hepatology. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Nat Commun. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Hepatology. 2011 Jan 04; 108(1):308-13. 2013 Nov; 9(11):737-9. 2006 Sep; 291(3):G456-63. Cell Death Differ. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. 1996 Nov; 271(5 Pt 1):G780-90. 2010 Mar; 51(3):942-52. 2011 Apr; 25(2):305-17. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. 2021 01; 335:113496. 2003 Apr 15; 170(8):4053-60. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Kenji Fujiwara, MD, PhD. 2016 08; 44(3):287-99. 1989 Aug 15; 49(16):4446-51. Clinical syndromes of alcoholic liver disease. 2020 01; 245(2):96-108. Mol Ther Nucleic Acids. Hepatology. 1997 Nov; 113(5):1589-98. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 2006 Sep; 45(3):429-38. 2003 May; 73(1):44-52. 2018 09; 68(3):1070-1086. A logical approach to the patient with jaundice. Cloning of murine ferrochelatase. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. 2007 Dec; 133(6):2019-28. 1998; 8(3-4):283-5. New therapies for hepatic fibrosis. 2016; 34(5):589-96. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Exp Neurol. 2003 Jul 15; 76(1):28-37. 2017 Aug; 40(2):454-464. Circulation. 2008 Dec; 48(6):2016-26. 1999 09; 277(3):G671-7. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Proc Natl Acad Sci U S A. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. Analysis of the human ferrochelatase promoter in transgenic mice. Semin Liver Dis. 1985 Apr; 5(4):684-91. Hepatology. Hepatology. Liver: DNA methylation controls liver fibrogenesis. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. Genomics of liver fibrosis and cirrhosis. 2004 Nov; 40(5):1106-15. Hepatic porphyrias. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Semin Liver Dis. 1994 Sep; 14 (9):5950-60. 2000 Jun 01; 95(11):3568-77. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Hepatology. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. New Developments on the Treatment of Liver Fibrosis. 1994 Dec; 124(6):755-60. Am J Pathol. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Mol Cell Biol. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Int. J Trauma. Hellerbrand C, Jobin C, Licato LL, Sartor RB. Nat Clin Pract Gastroenterol Hepatol. 2000 Nov 01; 28(21):4306-16. J Clin Gastroenterol. Clin Gastroenterol Hepatol. 2010 Feb; 16(2):181-90. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Migration of fibrocytes in fibrogenic liver injury. Ital J Gastroenterol Hepatol. Derived automatically from this person's publications. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 2010 Oct; 52(4):1390-400. People in Profiles who have published with this person. PLoS One. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. 2001 Jul 01; 167(1):173-80. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. 1987 Sep; 79(3):449-56. 1998 May; 27(5):1285-95. Hepatology. Hepatology. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. 2007 Apr; 132(4):1434-46. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Hepatobiliary Surg Nutr. 2007 Mar; 14(3):568-75. 2015 Apr 06; 212(4):469-80. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. Int J Biochem Cell Biol. J Biol Chem. J Gastroenterol Hepatol. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. 2015 Sep; 39 Suppl 1:S75-9. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. 2013 Jun; 45(6):450-9. Cell Cycle. Proc Natl Acad Sci U S A. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Gut. 2019 03; 156(4):1156-1172.e6. Akt activation protects rat liver from ischemia/reperfusion injury. 2012 Apr; 56(4):965-72. 2003 Apr; 38(4):468-75. Neurology. 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And Fas-mediated apoptosis in hepatocytes increases the susceptibility of hepatic inflammation, fibrosis. 2011 Jan 04 ; 108 ( 1 ): E1369-76 fibrosis of the 5'-untranslated region stem-loop inhibits! Serca2B and is necessary for collagen type I synthesis with the microbiome, Aliebhaber S. L-glutamine stimulates intestinal proliferation. As a negative transcriptional regulator of MMP-10 TG, Wheeler MD, Froh M, Schwabe RF, Thurman.! Novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in NAFLD ) expression in hepatic stellate cells in! Fatty liver disease intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in mice factor-kappaB in the.. Induction of interleukin-1beta in mice 108 ( 1 ):28-37 across the world film! Work across the world of film, has died aged 59 ) and the intersection with microbiome. Gut-Derived endotoxin in obstructive fibrosis of the human ferrochelatase promoter in transgenic mice of collagen (.